What is Defitelio? Uses, warnings & side effects

Updated May 14, 2025  •  Published Feb 14, 2024

Defitelio overview

BRAND NAMES:

  • Defitelio

Generic Names:

  • Defitelio

Uses:

  • Treats hepatic veno-occlusive disease after stem cell transplantation.

Therapeutic Classes:

  • Thrombolytic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Defitelio used for?

What form(s) does Defitelio come in?

  • Injectable

What are common Defitelio dosages?

  • Vial 2.5ml of 200mg/2.5ml

Defitelio images - What does Defitelio look like?

  • Defitelio
    2.5ml of 200mg/2.5ml vial

How to take Defitelio

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Defitelio

Defitelio contraindications - Who shouldn't take Defitelio?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to defibrotide.

Defitelio warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or bleeding problems.

  • This medicine may increase your risk of bleeding.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Confusion, headache, problems with vision or speaking

  • Lightheadedness, dizziness, fainting

  • Unusual bleeding, bruising, or weakness

Defitelio interactions & what to avoid when taking Defitelio

  • Do not use this medicine if you are also using alteplase or heparin.

  • This medicine may increase your risk of bleeding.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Defitelio side effects - How does Defitelio make you feel?

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, headache, problems with vision or speaking

  • Blood in urine or stools

  • Lightheadedness, dizziness, fainting

  • Chest pain, trouble breathing, coughing up blood

  • Unusual bleeding, bruising, or weakness

Less Serious Side Effects

  • Nausea, vomiting, diarrhea

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