Astagraf Xl is an extended-release prescription drug that prevents organ rejection after a kidney transplant. Astagraf Xl suppresses the immune system in combination with other immune-suppressing drugs, basiliximab, and mycophenolate. The active ingredient in Astagraf Xl, tacrolimus, slows down the immune system by blocking chemicals that activate white blood cells, the part of the immune system that protects the body from foreign tissues and infections. Astagraf Xl costs $216.95 at full price. A SingleCare Astagraf Xl coupon reduces that price to $169.04.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/21/2025
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Astagraf Xl is an extended-release prescription drug that prevents organ rejection after a kidney transplant. Astagraf Xl suppresses the immune system in combination with other immune-suppressing drugs, basiliximab, and mycophenolate. The active ingredient in Astagraf Xl, tacrolimus, slows down the immune system by blocking chemicals that activate white blood cells, the part of the immune system that protects the body from foreign tissues and infections. Astagraf Xl costs $216.95 at full price. A SingleCare Astagraf Xl coupon reduces that price to $169.04.
Astagraf Xl is an extended-release prescription drug that prevents organ rejection after a kidney transplant. Astagraf Xl suppresses the immune system in combination with other immune-suppressing drugs, basiliximab, and mycophenolate. The active ingredient in Astagraf Xl, tacrolimus, slows down the immune system by blocking chemicals that activate white blood cells, the part of the immune system that protects the body from foreign tissues and infections. Astagraf Xl costs $216.95 at full price. A SingleCare Astagraf Xl coupon reduces that price to $169.04.
At most pharmacies, the full cost of Astagraf Xl will be $216.95. That same prescription will cost $169.04 per 30, 1mg capsules using a SingleCare savings card, which you can use at participating pharmacies nationwide such as Target, Longs Drugs, and Fry's, among others.
Your copay on a Astagraf Xl prescription will depend on your insurance plan. With a SingleCare Astagraf Xl coupon, though, Astagraf Xl costs $169.04, which may be lower than your copay. To save money on Astagraf Xl, compare your insurance copay to SingleCare’s discount.
Medicare prescription drug insurance plans usually do not provide coverage for Astagraf Xl. However, Astagraf Xl is considered a necessary part of transplant surgery and so is covered by Medicare Part B as a medical benefit. If Medicare Part B does not cover Astagraf Xl, it will be covered by Medicare Part D. If you don't have Medicare coverage, consider using a SingleCare Astagraf Xl coupon for your prescription. With SingleCare, the price of Astagraf Xl is $169.04 for 30, 1mg capsules.
Astagraf Xl is a brand-name prescription drug with the active ingredient tacrolimus. Generic tacrolimus is available from manufacturers such as Apotex, Zydus, and Amneal, among others.
Astagraf Xl is a brand-name prescription drug that, in combination with basiliximab and mycophenolate, suppresses the immune system to prevent organ rejection after a kidney transplant. Tissues transplanted from one person to another are recognized by the body as a foreign invader. The body responds by attacking the transplanted tissue with an immune response. If the immune system successfully damages or kills the transplanted tissues, this is called tissue or organ rejection.
The active ingredient in Astagraf Xl, tacrolimus, however, “slows down” the immune system by blocking chemicals in the body that activate white blood cells, the cells that attack the newly transplanted organ.
Astagraf Xl is taken as a capsule once per day. A missed dose can be taken up to 14 hours after it should have been taken.
Astagraf Xl suppresses the immune system, the first line of defense against infections. So Astagraf Xl lowers the body's ability to prevent or fight infections, putting patients at a higher risk of infections, including severe and life-threatening infections. Immune suppression also increases the risk of certain types of cancer, such as skin cancer or lymphoma.
Other side effects include diarrhea, headache, nausea, vomiting, constipation, swelling, tremors, fatigue, insomnia, high blood sugar, high blood pressure, nerve damage, and high blood calcium. Allergic reactions are rare.
This is not a complete list of possible side effects. Consult with your prescribing physician and pharmacist about possible side effects before starting on Astagraf Xl.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved