Xatmep Coupons & Prices

Xatmep is a prescription oral solution prescribed to patients with acute lymphoblastic leukemia, a type of cancer, or polyarticular (multiple joints) juvenile rheumatoid arthritis. The active ingredient in Xatmep, methotrexate, both prevents swelling and prevents tumors from growing. The price for Xatmep is $2,828.58, but the price with a SingleCare Xatmep coupon is only $2,447.38.

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12 solution (quantity in ml)2.5mg/mlEdit

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Xatmep coupon at Kroger Pharmacy
$2450.38
$ 2,447
$3 off with signupwith signup

Show this free card to your pharmacist.

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Xatmep coupon at Harris Teeter Pharmacy
$2450.38
$ 2,447
$3 off with signupwith signup

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Xatmep coupon at CVS Pharmacy
$2557.64
$ 2,555
$3 off with signupwith signup
Xatmep coupon at Food Lion Pharmacy
$ 2,558
Xatmep coupon at Publix Pharmacy
$2618.41
$ 2,615
$3 off with signupwith signup
Xatmep coupon at Costco Pharmacy
$2645.41
$ 2,642
$3 off with signupwith signup
$2654.67
$ 2,652
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/21/2025

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About Xatmep

Xatmep is a prescription oral solution prescribed to patients with acute lymphoblastic leukemia, a type of cancer, or polyarticular (multiple joints) juvenile rheumatoid arthritis. The active ingredient in Xatmep, methotrexate, both prevents swelling and prevents tumors from growing. The price for Xatmep is $2,828.58, but the price with a SingleCare Xatmep coupon is only $2,447.38.

About Xatmep

Xatmep is a prescription oral solution prescribed to patients with acute lymphoblastic leukemia, a type of cancer, or polyarticular (multiple joints) juvenile rheumatoid arthritis. The active ingredient in Xatmep, methotrexate, both prevents swelling and prevents tumors from growing. The price for Xatmep is $2,828.58, but the price with a SingleCare Xatmep coupon is only $2,447.38.

Xatmep FAQs

How much does Xatmep cost without insurance?

Uninsured customers pay an average of $2,828.58, but Xatmep prices can vary. Visit a nearby participating pharmacy and pay only $2,447.38 with a SingleCare Xatmep coupon.

How much does Xatmep cost with insurance?

The amount of your Xatmep copay depends on your insurance plan. Xatmep costs $2,447.38 per 120, 2.5mg/ml solution (quantity in ml)s with a SingleCare discount card, which may be lower than your insurance copay. Consult with your pharmacist to compare your cost using insurance with your savings using SingleCare.

Does Medicare cover Xatmep and how much does it cost?

Xatmep is only sometimes covered by Medicare prescription drug plans, but if it isn't, it will most likely be covered under Medicare Part B. For patients without coverage, a SingleCare Xatmep coupon offers significant savings at major pharmacies: CVS, Target, Walgreens, and many others.

Is there a generic of Xatmep?

Xatmep is the only brand-name prescription oral solution with the active ingredient methotrexate. Generic methotrexate oral solution is not supplied at this time.

What is Xatmep?

Xatmep (methotrexate) is a prescription drug prescribed to patients with acute lymphoblastic anemia or with active polyarticular juvenile idiopathic arthritis (pJIA) that has not responded to other drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs).

The active ingredient in Xatmep, methotrexate, is an “antimetabolite,” that is, it prevents cells from carrying out basic functions (metabolism) they need to survive and divide. Xatmep is effective against tumors because it both prevents tumor cells from dividing and kills them.

Polyarticular juvenile idiopathic arthritis is a non-rheumatoid arthritis in children (juvenile) that affects five or more joints in the fingers (polyarticular). It results from the immune system mistakenly attacking healthy tissues, and the resulting inflammation causes fever, redness, and swelling in the joints. Methotrexate blocks the basic functions of the white blood cells that cause swelling and damage to the joint tissues.

Xatmep is taken as an oral solution once per week for patients who cannot swallow tablets. The oral form of methotrexate is used when low doses are required. The dose will depend on the underlying condition.

What are the side effects of Xatmep?

Severe side effects of Xatmep depend on the dose and length of treatment, but they include bone marrow suppression (putting the patient at risk of serious or fatal infections), liver damage, anemia, potentially irreversible lung disease, lymphomas, kidney problems, and infertility.

Xatmep is toxic to and will kill fetuses.

Common side effects of Xatmep include, but are not limited to, nausea, vomiting, diarrhea, headache, hair loss, and swelling in the mouth.

Allergic reactions are rare but potentially severe. These include Stevens-Johnson syndrome and toxic epidermal necrolysis, serious and potentially fatal skin reactions to Xatmep. Watch for any signs of an allergic reaction – fever, sore throat, flu symptoms, rash, or blisters – and immediately talk to a doctor if you suspect you're having an allergic reaction.

This is not a complete list of side effects. Please ask your physician if you have any concerns or questions about the possible side effects of Xatmep.

Where are Xatmep coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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