Treximet is an FDA-approved, brand-name drug used to help relieve headache, pain, and other migraine symptoms, such as nausea, vomiting, and sensitivity to light or sound. Naproxen-sumatriptan is the generic version of this drug. The average retail price of Treximet is around $1,540.22. You can use a SingleCare Treximet coupon to pay a reduced price of $124.95 when you shop at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/21/2025
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Treximet is an FDA-approved, brand-name drug used to help relieve headache, pain, and other migraine symptoms, such as nausea, vomiting, and sensitivity to light or sound. Naproxen-sumatriptan is the generic version of this drug. The average retail price of Treximet is around $1,540.22. You can use a SingleCare Treximet coupon to pay a reduced price of $124.95 when you shop at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Sumatriptan-Naproxen Sodium Retail Price | Sumatriptan-Naproxen Sodium SingleCare Price |
|---|---|---|
| CVS Pharmacy | $610.02 | $127.98 |
| Walgreens | $612.09 | $305.82 |
| Kroger Pharmacy | $900.99 | $209.52 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Treximet is an FDA-approved, brand-name drug used to help relieve headache, pain, and other migraine symptoms, such as nausea, vomiting, and sensitivity to light or sound. Naproxen-sumatriptan is the generic version of this drug. The average retail price of Treximet is around $1,540.22. You can use a SingleCare Treximet coupon to pay a reduced price of $124.95 when you shop at participating pharmacies.
If you have no insurance, the cash price of Treximet is around $1,540.22. You can fill or refill your Treximet prescription for $124.95 per 9, 85-500mg tablets when you use a SingleCare Treximet discount card. Our free coupons can be redeemed at various local pharmacies.
The cost of Treximet with your insurance plan generally depends on the type of health insurance plan you have. Talk to your insurance provider or your local pharmacist to determine your cost of Treximet with insurance. Using a SingleCare Treximet prescription discount card can help lower your Treximet prescription price to our lowest price of $124.95.
Treximet is currently not generally covered by Medicare prescription drug plans. With no coverage from Medicare for this prescription drug, Treximet patients may have to pay the full cash price of $1,540.22 for a typical Treximet prescription. SingleCare offers prescription savings cards that can help to reduce your total. The current lowest price with SingleCare is $124.95.
Treximet is manufactured by Currax Pharmaceuticals. The generic version of Treximet is naproxen-sumatriptan.
SingleCare coupons are accepted at most national pharmacies and grocery stores, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Simply text, email, print, or save your free Treximet coupon to your digital wallet and show your pharmacist at checkout.
Treximet is used to help relieve headache, pain, and other migraine symptoms, such as nausea, vomiting, and sensitivity to light or sound. It can be used to treat migraines with or without aura.
This drug combines sumatriptan and naproxen. Sumatriptan works by binding to 5-HT1B/1D receptors on blood vessels found in the brain. This action helps to narrow blood vessels in the brain, which is believed to help relieve migraine symptoms. It can also help reduce substances in the body that can trigger migraine symptoms. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works to block the production of prostaglandins, which are chemicals involved with inflammation and pain.
Treximet is only used to treat migraine headaches as soon as symptoms appear. It is not used as a preventative medicine for migraines. Treximet is not used to treat other types of headaches such as hemiplegic (migraines that cause you to be unable to move on one side of your body) or basilar migraines (a rare form of migraine with aura). This drug will not reduce the number of headaches you suffer from, only the symptoms.
Treximet should not be used if you have uncontrolled high blood pressure, blood circulation problems, a history of heart disease or heart bypass surgery, a history of heart attack or stroke, a heart rhythm disorder, severe liver disease, a history of a severe allergic reaction to aspirin or an NSAID, or if you are in late pregnancy.
Common side effects involved with the use of Treximet may include dizziness; drowsiness; weakness; muscle tightness; pain, discomfort, or stiffness in your neck, throat, jaw, or chest; nausea; heartbeat problems; heartburn; tingling or numbness in your fingers or toes; and feeling hot.
If you experience nausea that seems out of proportion to your migraine, sudden or severe, stomach pain, blood in your bowel movement or it is black and sticky like tar, blood in vomit, yellow skin or eyes, unusual weight gain, feeling more tired or weaker than usual, flu-like symptoms, itching, diarrhea, swelling of the arms, legs, hands, and feet, or tenderness in your upper right side, then you should stop taking Treximet immediately and see your doctor or your healthcare provider as soon as possible.
This is not a complete list of the possible side effects or drug interactions associated with Treximet use. Seek additional information and medical advice from your doctor or healthcare professional before taking Treximet.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved