Symbyax is a brand-name combination prescription drug used to treat depressive episodes in bipolar disorder (manic-depressive illness) as well as severe depression that does not respond to other medications. Symbyax combines an SSRI, fluoxetine, which treats depression, with an antipsychotic, olanzapine, which treats psychosis and mania. On average, the retail price of Symbyax is $367.47, but only costs $75.03 with a SingleCare Symbyax coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/21/2025
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Symbyax is a brand-name combination prescription drug used to treat depressive episodes in bipolar disorder (manic-depressive illness) as well as severe depression that does not respond to other medications. Symbyax combines an SSRI, fluoxetine, which treats depression, with an antipsychotic, olanzapine, which treats psychosis and mania. On average, the retail price of Symbyax is $367.47, but only costs $75.03 with a SingleCare Symbyax coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Symbyax is a brand-name combination prescription drug used to treat depressive episodes in bipolar disorder (manic-depressive illness) as well as severe depression that does not respond to other medications. Symbyax combines an SSRI, fluoxetine, which treats depression, with an antipsychotic, olanzapine, which treats psychosis and mania. On average, the retail price of Symbyax is $367.47, but only costs $75.03 with a SingleCare Symbyax coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
A prescription will cost around $367.47 for uninsured customers, but dosages may vary. With a SingleCare Symbyax coupon, you will pay only $75.03 per 30, 3-25mg capsules for the same prescription of Symbyax.
Your copay for Symbyax with insurance will vary depending on your plan and the dosage required. Ask your pharmacist to compare your insurance copay to SingleCare. You may find your SingleCare discount card saves you money—with SingleCare, Symbyax only costs $75.03.
Symbyax is usually not covered for Medicare-eligible patients under Medicare Part D and Medicare Advantage, but the generic, olanzapine-fluoxetine, is. Medicare patients can save money on a prescription for Symbyax with SingleCare Symbyax coupons—the price of Symbyax with a SingleCare discount card is only $75.03.
Symbyax is a brand-name prescription drug and several pharmaceutical companies manufacture generic Symbyax, including Par, Sandoz, and Teva. Before you pay for your Symbyax prescription, find free coupons for Symbyax or generic olanzapine-fluoxetine on our website or app.
Symbyax is a brand-name combination prescription drug used to treat depressive episodes in bipolar disorder (manic-depressive illness) as well as severe depression that does not respond to other medications.
Fluoxetine belongs to a class of drugs called SSRIs (selective serotonin reuptake inhibitors). These drugs work by preventing chemicals important to nerve cell communication from being reabsorbed back into nerve cells. SSRIs, you might say, keep the communication channels between nerve cells open for a longer period of time. This strengthens circuits in the brain that are vital to regulating mood.
Olanzapine treats manic periods of bipolar disorder (manic-depressive illness) by blocking the brain activity that causes mania.
Although not a complete list, common side effects of Symbyax include diarrhea, weight gain, increased appetite, drowsiness, dizziness, decreased sex drive, insomnia, and shaking. Mental and mood changes can be severe and include confusion, nervousness, trouble concentrating, and restlessness. Allergic reactions to Symbyax are rare but include rashes, hives, and swelling. Severe skin reactions, such as Stevens-Johnson syndrome, are possible but very rare; these are marked by body-wide blistering and bleeding, fever, and liver damage.
Symbyax increases the amount of serotonin in the body. Too much serotonin (serotonin syndrome) can cause moderate to severe side effects, such as fever, agitation, overactive reflexes, dilated pupils, hallucinations, and sweating.
The most serious side effects are low sodium levels, high blood sugar, elevated risk for stroke or heart attack, and, most seriously, suicidal thoughts for patients under the age of 24. Prolonged use of Symbyax can result in a movement disorder that may not be reversible, characterized by involuntary muscle movements of the face, eyes, tongue, arms, and legs.
Symbyax is not an addictive drug, but may have withdrawal symptoms when discontinued abruptly.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved