What is Ravicti? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Ravicti overview

BRAND NAMES:

  • Ravicti

Generic Names:

  • Ravicti

Uses:

  • Treats urea cycle disorders to help remove nitrogen from the body.

Therapeutic Classes:

  • Hyperammonemia Agent

Forms:

  • Liquid

How it’s taken:

  • By mouth

What is Ravicti used for?

Ravicti works by managing ammonia levels in patients diagnosed with urea cycle disorder to prevent neurological disorders. Ravicti is taken in combination with a low-protein diet and it is prescribed to patients older than 2 months of age. This prescription-only medication is available as an oral liquid.

What form(s) does Ravicti come in?

  • Liquid

What are common Ravicti dosages?

  • Bottle 25ML of 1.1GM/ML

Ravicti images - What does Ravicti look like?

  • Ravicti
    25ml of 1.1gm/ml bottle

How to take Ravicti

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • This medicine may be given through a feeding tube (nasogastric tube or gastrostomy tube).

  • Use an oral syringe to measure the dose. Place it on the tip of the feeding tube.Inject the medicine into the tube.Flush the tube with 10 milliliters (mL) of water to rinse all of the medicine into the stomach.Rinse the tube again with another 10 mL of water to clear the tube.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Use an oral syringe to measure the dose. Place it on the tip of the feeding tube.Inject the medicine into the tube.Flush the tube with 10 milliliters (mL) of water to rinse all of the medicine into the stomach.Rinse the tube again with another 10 mL of water to clear the tube.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine may be given through a feeding tube (nasogastric tube or gastrostomy tube).

What to do if you miss a dose of Ravicti

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ravicti contraindications - Who shouldn't take Ravicti?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to glycerol phenylbutyrate.

Ravicti warnings

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, nerve problems, or digestive problems (including pancreas problems). Tell your doctor if you have used a phenylbutyrate medicine in the past.

  • Do not breastfeed during treatment with this medicine. But you may use this medicine just before breastfeeding.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Nausea or vomiting, seizures, yellow eyes or skin

  • Unusual sleepiness, tiredness, or weakness

Ravicti interactions & what to avoid when taking Ravicti

  • Some medicines can affect how glycerol phenylbutyrate works. Tell your doctor if you are using any of the following:Alfentanil, cyclosporine, haloperidol, midazolam, probenecid, quinidine, valproic acidSteroid medicine (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Make sure your doctor knows if you have used a phenylbutyrate medicine before.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Ravicti side effects - How does Ravicti make you feel?

Serious Side Effects

  • Unusual sleepiness, tiredness, or weakness

  • Nausea, vomiting, seizures, yellow eyes or skin

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Burning, tingling, numbness or pain in the hands, arms, feet, or legs

  • Confusion, memory problems

  • Lightheadedness, headache, trouble hearing

Less Serious Side Effects

  • Decreased appetite

  • Diarrhea, gas, stomach pain

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