What is Nalbuphine? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Nalbuphine overview

BRAND NAMES:

  • Nalbuphine HCl Novaplus, Nalbuphine HCl Novaplus

Generic Names:

  • Nalbuphine Hcl

Uses:

  • Treats various types of severe pain. Also used during anesthesia, surgery, or childbirth. This medicine is a narcotic pain medicine.

Therapeutic Classes:

  • Analgesic, Anesthetic Adjunct

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Nalbuphine used for?

What form(s) does Nalbuphine come in?

  • Injectable

What are common Nalbuphine dosages?

  • Vial 10ML of 10MG/ML

  • Vial 10ML of 20MG/ML

  • Ampule 1ML of 10MG/ML

  • Ampule 1ML of 20MG/ML

Nalbuphine images - What does Nalbuphine look like?

  • Nalbuphine HCl
    1ml of 10mg/ml ampule

  • Nalbuphine HCl
    1ml of 20mg/ml ampule

  • Nalbuphine HCl
    10ml of 10mg/ml vial

  • Nalbuphine HCl
    10ml of 20mg/ml vial

How to take Nalbuphine

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin, into a muscle, or into a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Look at the medicine before injecting it. If it has changed color, or has particles in it, do not use it. Call your doctor or pharmacist.

  • It may take as long as 15 minutes after injection for you to feel any pain relief. Do not use more medicine than your doctor has ordered.

  • It may take as long as 15 minutes after injection for you to feel any pain relief. Do not use more medicine than your doctor has ordered.

  • Look at the medicine before injecting it. If it has changed color, or has particles in it, do not use it. Call your doctor or pharmacist.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin, into a muscle, or into a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

What to do if you miss a dose of Nalbuphine

  • Do not take two doses at the same time.

  • Use your medicine as soon as possible unless it is almost time for your next dose.

  • Skip the missed dose if it is almost time for your next regular dose.

Nalbuphine contraindications - Who shouldn't take Nalbuphine?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to nalbuphine, or if you have severe breathing problems or stomach blockage (such as paralytic ileus).

Nalbuphine warnings

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (such as asthma, bronchitis, COPD, sleep apnea), adrenal problems, gallbladder or pancreas problems, heart attack, slow heartbeat, or a history of brain tumor, head injury, depression, mental health problems, or seizures. Tell your doctor if you are addicted to drugs or alcohol.

  • This medicine may cause the following problems:High risk of overdose, which can lead to death Respiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Nalbuphine interactions & what to avoid when taking Nalbuphine

  • Some medicines can affect how nalbuphine works. Tell your doctor if you are using any of the following:Cyclobenzaprine, metaxalone, mirtazapine, tramadol, trazodoneBenzodiazepine medicineDiuretic (water pill)MAO inhibitorMedicine to treat anxiety, depression, or mental health problemsPhenothiazine medicineTriptan medicine to treat migraine headaches

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, pentazocine, or a muscle relaxer.

  • Do not drink alcohol while you are using this medicine.

  • This medicine may make you drowsy or dizzy. Avoid driving a car or using machinery after using a dose of this medicine.

  • This medicine is a very strong pain killer, and may be habit-forming. Do not use more than your doctor ordered, or use it for longer periods of time than prescribed.

  • Talk to your doctor before you stop using this medicine. You may need to use smaller and smaller doses before stopping completely.

Nalbuphine side effects - How does Nalbuphine make you feel?

Serious Side Effects

  • Severe confusion, lightheadedness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Blue lips, fingernails, or skin

  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures

  • Severe constipation or stomach pain

Less Serious Side Effects

  • Nausea or vomiting

  • Sleepiness

  • Pain, itching, burning, swelling, or a lump under your skin where the shot was given

  • Sleepiness

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