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Key takeaways
Zyrtec and Pepcid are both available over the counter and by prescription, and they both block histamine receptors.
The effects of Zyrtec are most profound in the respiratory system and skin, providing relief from allergy symptoms like itchiness and runny nose.
Pepcid may assist with treatment of allergies, but it is most commonly tasked with blocking histamine-mediated acid production in the stomach in cases of acid reflux disease and stomach ulcers.
When the circumstances call for it, healthcare providers may advise the use of both Zyrtec and Pepcid for allergy symptoms, or if allergies and stomach problems are both occurring.
Starting either drug is a matter best discussed with your healthcare provider, who can determine whether it’s the best option for you.
There are several reasons one may consider taking Zyrtec and Pepcid together. They both block histamine receptors, but their mechanisms are different enough to have additive benefits. Zyrtec (cetirizine) is an antihistamine used for allergies, while Pepcid (famotidine) blocks gastric histamine-2 (H2) receptors and thereby decreases stomach acid production in the treatment of gastroesophageal reflux disease (GERD) and stomach ulcers. There are certain situations when your healthcare provider may recommend taking Zyrtec and Pepcid together, although it may not be advisable for everyone.
Can you take Zyrtec and Pepcid together?
Zyrtec and Pepcid can be taken together in a couple of different circumstances. For example, someone may benefit from taking Zyrtec if they have seasonal or perennial allergies. And if they coincidentally experience heartburn, Pepcid can help.
In addition, there are occasions that call for multiple ways to block histamine. Zyrtec blocks histamine-1 (H1) receptors, just like its fellow antihistamines Allegra (fexofenadine), Claritin (loratadine), and Benadryl (diphenhydramine). H1 receptors are located in various organs, including the skin, respiratory tract, and intestinal tract. Zyrtec can help reduce allergy symptoms mediated by H1 receptors, such as hives, itching, and runny nose. By blocking H2 receptors in similar body systems, Pepcid could bolster the symptom relief provided by Zyrtec, even if it is not as effective as Zyrtec or used independently for these issues.
How to take Zyrtec and Pepcid together
Knowing that the two drugs can be taken together does not mean that you should take them together. Although they are available over the counter with a prescription, Zyrtec and Pepcid have potential side effects and drug interactions like any other medicine. It is worthwhile asking your healthcare provider before starting one or both of these drugs.
The treating healthcare professional may recommend an alternative to either medication. For example, a leukotriene receptor antagonist like Singulair (montelukast) could be advised rather than Zyrtec for allergies. Or, your healthcare provider may recommend a proton pump inhibitor like Prilosec (omeprazole) instead of the H2 blocker Pepcid for GERD.
Healthcare providers may have helpful input on when to take these histamine blockers. If Zyrtec and Pepcid are both advised, Pepcid is often taken at bedtime for acid reflux, as opposed to Zyrtec, which is commonly taken in the morning for allergies. When deemed necessary, such as with stubborn allergy symptoms, the two drugs could be taken at the same time.
Pepcid and Zyrtec interactions and side effects
Pepcid’s side effects are not typically frequent or severe. Some of the most common adverse reactions include dizziness, diarrhea, constipation, taste disturbances, agitation, and vitamin B12 deficiency with prolonged use. Talk to your healthcare provider and pharmacist about these and any serious side effects to be aware of.
Similarly, Zyrtec is generally well-tolerated. Among the list of Zyrtec’s most common side effects are tiredness, headache, diarrhea, and dry mouth. Serious side effects are possible, although less likely, and it is worth discussing them with your healthcare team.
Drug interactions are an issue that patients and healthcare providers should always recognize. Pepcid can alter the absorption and effects of some other drugs, such as the antibiotic cefuroxime. Zyrtec can create additive drowsiness when combined with medications like opioids, benzodiazepines, sleep aids, and alcohol. It’s important to share your list of prescription drugs, over-the-counter medications, and supplements with your healthcare providers and pharmacists in order to prevent such interactions.
Zyrtec and Pepcid comparison
Zyrtec blocks H1 receptors in order to provide relief from allergy symptoms like itching, watery eyes, runny nose, and sneezing. As a second-generation antihistamine, it does not cause as much drowsiness as first-generation versions like Benadryl, but it can still be problematic for some individuals, particularly older adults and those on other sedating drugs. Your healthcare provider can give you ways to leverage Zyrtec’s benefits while avoiding its adverse effects.
Pepcid may help a bit with allergy symptoms but is widely used to lessen heartburn symptoms in GERD by blocking H2 receptors. With Pepcid’s most profound effects being within the gastrointestinal tract, its adverse reactions and drug interactions involve problems like altered bowel habits, taste disturbance, and changes in absorption of other pills. Ask your healthcare provider whether these uses or risks of Pepcid apply to you.
The two drugs are both available by prescription or over the counter. Depending on your insurance formulary and copay requirements, you may find it is cheaper to get them using a free and easy-to-use SingleCare prescription discount card.
Zyrtec vs. Pepcid: Comparison chart |
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|---|---|---|
| Zyrtec | Pepcid | |
| Drug class | Antihistamine | Antacid |
| Standard dosage and forms | 10 mg once daily | 20 mg once daily |
| Risks and restrictions to consider |
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| Side effects |
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| Average cost without insurance | $30 for 30, 10 mg tablets | $971 for 60, 20 mg tablets |
| SingleCare cost | Get coupon | Get coupon |
| Learn more | More Zyrtec details | More Pepcid details |
Bottom line
Taking Zyrtec and Pepcid together can be permissible and advisable for certain health conditions. Although generally safe, this drug duo does have potential side effects. While they do not negatively interact with one another, they can interact with other drugs. Check with your healthcare provider to see if you should use both drugs for additive allergy relief or if it’s okay to use Zyrtec for allergies and Pepcid for GERD or stomach ulcers.
Sources
- Antihistamines and allergy, Australian Prescriber (2018)
- Cetirizine drug page, StatPearls (2024)
- Famotidine drug page, StatPearls (2024)