Zepbound vs. Mounjaro: Compare effectiveness, coverage, side effects, and costs

In this article:

• Main differences between Zepbound and Mounjaro
• Conditions treated by Zepbound and Mounjaro
• Efficiacy
• Cost and coverage
• Side effects
• Interactions
• Warnings
• FAQs

In this article

• Main differences between Zepbound and Mounjaro
• Conditions treated by Zepbound and Mounjaro
• Efficiacy
• Cost and coverage
• Side effects
• Interactions
• Warnings
• FAQs

If you or someone you know experiences weight-related challenges or Type 2 diabetes, medications like Zepbound and Mounjaro might be part of the conversation when it comes to treatment options. These medications both involve a weekly injection and share the same active ingredient, tirzepatide. As a dual glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide can help control appetite and decrease sugar levels. 

Although both brand-name medications are deemed effective and have identical side effects, they may differ in other ways. For example, they have different approved uses and may have differences in insurance coverage. Continue reading to learn more about the similarities and differences between Zepbound and Mounjaro. 

What are the main differences between Zepbound and Mounjaro?

Although Zepbound and Mounjaro contain the same active ingredient tirzepatide, they’re approved for different uses. Mounjaro was approved by the Food and Drug Administration in May of 2022 to help manage Type 2 diabetes. Zepbound was approved in November 2023 for weight loss purposes. 

Insurance often pays for medicines like Mounjaro to treat Type 2 diabetes, but they might not do the same for weight loss drugs like Zepbound. This means that getting approval to use them can differ depending on a person’s main health condition and what the doctor or healthcare provider recommends. Because insurance doesn’t usually cover weight loss medications, you might have to pay more out-of-pocket for Zepbound than Mounjaro.

Other than these differences, Zepbound and Mounjaro are identical. Both Zepbound and Mounjaro are manufactured by Eli Lilly and administered as a weekly injection under the skin (subcutaneous). They both also come in single-dose pens or vials in strengths of 2.5, 5, 7.5, 10, 12.5, and 15 mg per mL. 

Main differences of Zepbound versus Mounjaro
	Zepbound	Mounjaro
Drug class	GIP and GLP-1 receptor agonist	GIP and GLP-1 receptor agonist
Brand/generic status	Brand version only	Brand version only
What is the generic name?	Tirzepatide	Tirzepatide
What form(s) does the drug come in?	Subcutaneous injection as a single-dose pen or vial	Subcutaneous injection as a single-dose pen or vial
What is the standard dosage?	2.5 mg injected under the skin once weekly for 4 weeks. Then, the dosage is increased to 5 mg once weekly.  The dosage may be increased in 2.5 mg increments after at least 4 weeks on the present dose up to a maximum of 15 mg once weekly, depending on the treatment response.	2.5 mg injected under the skin once weekly for 4 weeks. Then, the dosage is increased to 5 mg once weekly.  The dosage may be increased in 2.5 mg increments after at least 4 weeks on the present dose up to a maximum of 15 mg once weekly, depending on the treatment response.
How long is the typical treatment?	Long-term	Long-term
Who typically uses the medication?	Adults 18 and older	Adults 18 and older

Conditions treated by Zepbound and Mounjaro

Zepbound and Mounjaro are approved for different health conditions. Zepbound is FDA-approved for chronic weight management in adults struggling with obesity or who are overweight with weight-related health conditions. These conditions may include high blood pressure, heart disease, and Type 2 diabetes. In addition, Zepbound has been approved for obstructive sleep apnea (OSA). 

In contrast, Mounjaro is a diabetes drug. It is specifically approved by the FDA for Type 2 diabetes. Mounjaro is prescribed to help control high blood sugar levels by increasing the release of insulin and decreasing glucagon levels. While it may sometimes be prescribed off-label for weight loss, its primary use is for diabetes.

Both medications are recommended to be used alongside a diet and exercise plan. Therefore, lifestyle changes can greatly affect the outcomes and how well these drugs work. 

Is Zepbound or Mounjaro more effective?

When it comes to weight loss, both Zepbound and Mounjaro have shown impressive results. In a 72-week phase 3 clinical trial, participants who received the highest dose of tirzepatide (15 mg) once weekly—along with a reduced-calorie diet and increased physical activity—lost an average of around 21% of their baseline body weight. In comparison, those who took a placebo saw only around a 3% reduction in body weight.

Tirzepatide has also been shown to be effective in managing Type 2 diabetes. In a study called SURPASS-1, patients with Type 2 diabetes who took 5 mg, 10 mg, or 15 mg of tirzepatide alone saw their A1C levels (a measure of blood sugar control) decrease by around 2% after 40 weeks. In comparison, those who took a placebo only saw less than half a percent decrease in A1C levels. 

While Zepbound and Mounjaro have shown promising results in studies, individual results may vary. It’s always best to talk to a healthcare professional to figure out the most appropriate treatment plan for you.

Coverage and cost comparison of Zepbound vs. Mounjaro

Zepbound and Mounjaro are brand-name medications, with no generic alternatives available. Insurance coverage for these drugs can vary. In many cases, private insurance companies and Medicare won’t cover weight-loss medications as they may be considered cosmetic instead of medically necessary. Some insurance plans, including Medicare, might cover part of the cost of these medications, but it depends on the specific plan and insurance company. 

In general, insurance plans are more likely to cover Mounjaro for Type 2 diabetes than Zepbound for weight loss. However, Zepbound’s new FDA approval for OSA has opened it up to broader coverage when prescribed for this purpose. Still, after prior authorization, Zepbound may be covered for weight loss by some insurance plans.

Retail prices for Zepbound and Mounjaro differ based on dosage and quantity. The average retail costs of both medications can reach around $1,000 per month. Costs can change based on the pharmacy where the medication is purchased. However, those looking to save money on prescriptions like Zepbound and Mounjaro can explore options like the SingleCare discount card. 

Zepbound vs. Mounjaro costs
	Zepbound	Mounjaro
Typically covered by insurance?	No	Yes
Typically covered by Medicare Part D?	No	Yes
Quantity	4 prefilled injection pens	4 prefilled injection pens
Typical Medicare copay	Varies	Varies
SingleCare cost	$938	$872

Common side effects of Zepbound vs. Mounjaro

Both Zepbound and Mounjaro cause identical side effects. The most common side effects of Zepbound and Mounjaro include:

• Nausea
• Vomiting
• Stomach or abdominal pain
• Constipation
• Diarrhea
• Indigestion

In addition to these side effects, hair loss, heartburn, and fatigue have been reported in people taking Zepbound. Many people experience these effects when they start the medication, but they usually decrease in severity as the body adjusts. 

Serious side effects are rare but may include allergic reactions, kidney problems, low blood sugar (hypoglycemia), depression, and vision changes, among others. If you notice severe symptoms, seek immediate medical attention.

Drug interactions of Zepbound vs. Mounjaro

Zepbound and Mounjaro interact with many of the same drugs. These interactions may involve the following:

• Insulin or secretagogues (e.g., sulfonylureas): Both Zepbound and Mounjaro can lower blood sugar levels, potentially increasing the risk of hypoglycemia when used with insulin or insulin secretagogues. Healthcare providers may recommend adjusting the dose of these co-administered medications. 
• Oral medications: Zepbound and Mounjaro can slow down how quickly your stomach empties. This can change how some pills (like warfarin for blood clots or oral contraceptives for birth control) are absorbed. You may need a different dose or a non-oral birth control method while using these medications. 

Talk to a healthcare provider about potential interactions if you’re taking other medications. Include whether you’re taking prescription drugs, over-the-counter medicines, and herbal supplements.

Warnings of Zepbound and Mounjaro

Zepbound and Mounjaro share similar warnings. Do not use these medicines if you or someone in your family has had medullary thyroid cancer (MTC) or a condition called multiple endocrine neoplasia syndrome type 2 (MEN 2). You should also avoid these medications if you have ever had a serious allergic reaction to tirzepatide (such as severe swelling or trouble breathing).

These medicines can cause serious stomach or gut problems, including nausea, vomiting, or diarrhea. In some cases, this can lead to dehydration and kidney problems. These drugs may also increase the risk of gallbladder problems like gallstones or gallbladder inflammation. Pancreatitis (swelling of the pancreas) has also been reported in some people who took these medications. 

Both medications can lower your blood sugar, especially if you already use insulin or certain diabetes drugs called sulfonylureas. Watch for warning signs of low blood sugar, such as shakiness or sweating, and let your healthcare provider know about any unusual symptoms. If you have diabetes, be aware that sudden changes in blood sugar can sometimes worsen eye problems. 

Consult a healthcare provider for other possible warnings and precautions before using Zepbound or Mounjaro. 

Frequently asked questions about Zepbound vs. Mounjaro

What is Zepbound?

Zepbound is a prescription medication used for weight management in adult patients with obesity or who are overweight with at least one weight-related health condition, such as high blood pressure, Type 2 diabetes, or high cholesterol. It belongs to a class of drugs called GIP and GLP-1 receptor agonists that help regulate appetite and food intake. Zepbound is typically administered as a weekly dose through a single-use injection pen.

What is Mounjaro?

Mounjaro is a prescription medication approved by the FDA for the treatment of Type 2 diabetes in adult patients. Like Zepbound, it contains the active ingredient tirzepatide, which works by activating both GIP and GLP-1 receptors. While not specifically approved for weight loss, Mounjaro may be prescribed off-label for this purpose.

Are Zepbound and Mounjaro the same?

Zepbound and Mounjaro are essentially the same drug, containing the active ingredient tirzepatide. The main difference is that they are approved by the FDA for different uses: Zepbound for chronic weight management and Mounjaro for Type 2 diabetes. Both medications are manufactured by Eli Lilly and Company but marketed under different brand names for their respective indications.

Is Zepbound or Mounjaro better?

Since Zepbound and Mounjaro contain the same active ingredient, they are expected to have similar effects on weight loss and blood sugar control. The choice between the two medications depends on a person’s specific medical condition and the condition for which the drug is being prescribed. It’s important to consult a healthcare provider to determine the best option.

Can I use Zepbound or Mounjaro while pregnant?

The safety of using Zepbound or Mounjaro during pregnancy has not been studied. Animal studies have shown potential risks to an unborn baby, but there is limited data on the use of these medications in pregnant women. If you are pregnant, planning to become pregnant, or become pregnant while taking these medications, tell your healthcare provider immediately. 

Can I use Zepbound or Mounjaro with alcohol?

Consuming alcohol while taking Zepbound or Mounjaro may increase the risk of certain side effects, such as nausea, vomiting, and dizziness. Excessive alcohol consumption can also contribute to weight gain and may counteract the weight loss effects of these medications. It is generally recommended to limit alcohol intake while taking these prescription medications.