Search for articles or Rx savings
Key takeaways
Wellbutrin (bupropion) and Prozac (fluoxetine) are both FDA-approved for treating major depressive disorder, but they belong to different drug classes and work via distinct mechanisms, with Wellbutrin affecting norepinephrine and dopamine, and Prozac targeting serotonin levels.
Despite their efficacy in treating depression, Wellbutrin and Prozac have different side effect profiles. Wellbutrin is less likely to cause sexual side effects and weight gain compared to Prozac and other SSRIs.
Wellbutrin is available in three formulations (immediate-release, sustained-release, and extended-release) and is also used to support smoking cessation, while Prozac is available as a daily or weekly oral capsule and treats a broader range of conditions including OCD and bulimia.
Both medications carry black box warnings regarding the increased risk of suicidal thoughts and behaviors and have specific drug interactions and warnings that should be carefully considered with a healthcare provider before starting treatment.
Main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ
Wellbutrin (bupropion) and Prozac (fluoxetine) are medications that can treat depression. Specifically, these drugs are prescribed to treat major depressive disorder. Symptoms of major depressive disorder may include feelings of sadness or hopelessness, loss of interest in daily activities, and problems with sleep.
Wellbutrin and Prozac are only available with a prescription from a doctor or healthcare provider. Although they have similar uses, Wellbutrin and Prozac work in different ways and have different side effects. Continue reading to learn more about the similarities and differences between Wellbutrin and Prozac.
What are the main differences between Wellbutrin and Prozac?
Wellbutrin is an aminoketone antidepressant that is also known by its generic name, bupropion. The exact way in which Wellbutrin works is not well understood. However, it is believed to increase levels of certain neurotransmitters called norepinephrine and dopamine in the brain. Individuals with depression may have an imbalance of these neurotransmitters. Unlike other commonly prescribed antidepressants, Wellbutrin has no effect on serotonin levels.
Wellbutrin is available in three different formulations: immediate-release (IR), sustained-release (SR), and extended-release (XL). Depending on the dosage form, Wellbutrin can be taken once, twice, or three times daily. The active ingredient in Wellbutrin, bupropion, is also marketed as Zyban to support smoking cessation.
Prozac is one of the most commonly prescribed antidepressants. It is also known by the generic name fluoxetine. Prozac belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). These drugs work by increasing levels of the neurotransmitter serotonin to ease symptoms of depression.
Prozac comes as a daily oral capsule. The exact dosage depends on the condition being treated. Prozac is also available as a delayed-release capsule that is taken once per week.
| Differences between Wellbutrin and Prozac | ||
|---|---|---|
| Wellbutrin | Prozac | |
| Drug class | Aminoketone | Selective serotonin reuptake inhibitor |
| Brand/generic status | Brand and generic available | Brand and generic available |
| What is the generic name? | Bupropion | Fluoxetine |
| What form(s) does the drug come in? | Oral tablet | Oral capsule, Delayed-release |
| What is the standard dosage? | 100 mg three times daily Dosage dependent on condition |
20 mg once per day Dosage dependent on condition |
| How long is the typical treatment? | Long term depending on the condition being treated | Long term depending on the condition being treated |
| Who typically uses the medication? | Adults | Adults; children 8 years and older (depression) |
Conditions treated by Wellbutrin and Prozac
All forms of Wellbutrin are approved by the Food and Drug Administration (FDA) to treat major depressive disorder, also known as major depression. Wellbutrin XL, the extended-release form of Wellbutrin, is also approved to prevent seasonal affective disorder (SAD), a type of depression that develops during seasonal changes. Wellbutrin is sometimes used off-label to treat bipolar disorder.
Prozac is FDA approved to treat major depressive disorder. It is also approved to treat obsessive-compulsive disorder (OCD) and panic disorder, as well as an eating disorder called bulimia nervosa. When used along with an antipsychotic called Zyprexa (olanzapine), Prozac is used to treat depressive episodes in those with bipolar disorder. Some individuals with depression may not respond to other medications and thus, they may be prescribed Prozac and Zyprexa (olanzapine). Prozac is marketed under a different brand name called Sarafem to treat premenstrual dysphoric disorder.
Wellbutrin and Prozac have also been studied for the treatment of ADHD. One study found that Wellbutrin helped improve symptoms of ADHD compared to placebo.
| Condition | Wellbutrin | Prozac |
| Major depression | Yes | Yes |
| Depression associated with seasonal affective disorder | Yes | Off-label |
| Depression associated with bipolar I disorder | Off-label | Yes |
| Obsessive-compulsive disorder (OCD) | No | Yes |
| Panic disorder | No | Yes |
| Bulimia nervosa | No | Yes |
| Premenstrual dysphoric disorder (PMDD) | No | Yes |
| Attention-deficit hyperactivity disorder (ADHD) | Off-label | Off-label |
Is Wellbutrin or Prozac more effective?
Wellbutrin and Prozac are effective prescription medications for treating depression. The best antidepressant will depend on a number of factors such as cost, individual response to treatment, and potential side effects. Consult a healthcare provider on the best treatment options for your condition.
According to one double-blind comparison study, bupropion and fluoxetine were found to be similar in effectiveness for the treatment of depression. The study was conducted over seven weeks and utilized the Hamilton Rating Scale for Depression among other tools to assess treatment efficacy. Both bupropion and fluoxetine helped relieve depression symptoms with no severe adverse effects.
One systematic review found that Wellbutrin is an effective and safe medication compared to other antidepressants. Wellbutrin may have less side effects compared to SSRIs. It also causes less sexual side effects and weight gain than other antidepressants.
A systematic review found that Prozac is an effective medication for several mental health conditions, including depression, bulimia, and OCD. Prozac was found to be more effective than placebo in some studies within the review. It was also found to be as effective as Anafranil (clomipramine) for treating OCD.
Coverage and cost comparison of Wellbutrin vs. Prozac
The average cost of Wellbutrin XL without insurance is around $194. Wellbutrin XL is available in a generic form that is usually covered by most Medicare and health insurance plans. With a SingleCare prescription discount card, you may be able to lower the cost of the generic Wellbutrin XL to around $5, depending on the dosage and quantity prescribed.
Prozac is available in a generic form. It is usually covered by most insurance plans. The average cash price of Prozac is around $300. However, the price can vary depending on the dosage and quantity prescribed. A SingleCare prescription discount card for generic Prozac is available, which can help lower the cost to $4.
| Wellbutrin | Prozac | |
| Typically covered by insurance? | Yes | Yes |
| Typically covered by Medicare Part D? | Yes | Yes |
| Quantity | 30 tablets | 30 capsules |
| Typical Medicare copay | $0–$2 | $12 |
| SingleCare cost | $5 | $4–$20 |
Common side effects of Wellbutrin vs. Prozac
The most common side effects of Wellbutrin are dry mouth, nausea, dizziness, insomnia, stomach upset, anxiety, palpitations, and sweating. Wellbutrin may also cause muscle aches, rash, and itching. Weight changes have also been reported while using Wellbutrin. However, Wellbutrin is more likely to cause weight loss than weight gain.
The most common side effects or Prozac include sexual dysfunction, decreased sex drive, diarrhea, indigestion, nausea, fatigue, dizziness, and drowsiness. Prozac may also cause rash, flu-like symptoms, and tremors. Weight changes have also been reported with Prozac.
Severe side effects of Wellbutrin and Prozac include worsened depression and suicidal thoughts or behaviors. Seek immediate medical attention if you experience worsened depression symptoms. You should also seek medical attention if you experience an allergic reaction to Wellbutrin or Prozac. Symptoms of an allergic reaction include hives, trouble breathing, or swelling of the face or throat.
| Wellbutrin | Prozac | |||
| Side effect | Applicable? | Frequency | Applicable? | Frequency |
| Nausea | Yes | 13% | Yes | 22% |
| Indigestion | Yes | 3% | Yes | 8% |
| Dry Mouth | Yes | 17% | Yes | 9% |
| Constipation | Yes | 10% | Yes | 5% |
| Diarrhea | Yes | 5% | Yes | 11% |
| Muscle pain | Yes | 2% | No | – |
| Anxiety | Yes | 5% | Yes | 12% |
| Rash | Yes | 5% | Yes | 4% |
| Dizziness | Yes | 7% | Yes | 9% |
| Somnolence | Yes | 2% | Yes | 12% |
| Tremor | Yes | 6% | Yes | 9% |
| Insomnia | Yes | 11% | Yes | 19% |
| Decreased libido | No | – | Yes | 4% |
| Palpitations | Yes | 2% | Yes | 1% |
Source: DailyMed (Wellbutrin SR), DailyMed (Prozac)
Drug interactions of Wellbutrin vs. Prozac
Wellbutrin should not be combined with a monoamine oxidase inhibitor (MAOI), such as selegiline or phenelzine. Taking Wellbutrin with an MAOI can increase the risk of high blood pressure. Prozac should also be avoided with an MAOI. Combining Prozac with an MAOI can increase the risk of serotonin syndrome, a condition that may require hospitalization. Wellbutrin or Prozac should also not be taken within 14 days of stopping an MAOI.
Dopaminergic drugs like levodopa and amantadine can interact with Wellbutrin. Using these medications with Wellbutrin can increase the risk of adverse effects, such as restlessness, dizziness, and tremors.
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) or warfarin should be avoided or monitored while taking Prozac. This drug interaction may lead to an increased risk of bleeding.
Prozac can also interact with other serotonergic drugs like certain opioids, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors (SNRIs), seizure medications, and mood stabilizers. Taking these medications with Prozac may increase the risk of serotonin syndrome.
| Drug | Drug class | Wellbutrin | Prozac |
| Selegiline Rasagiline Isocarboxazid Phenelzine |
MAOIs | Yes | Yes |
| Levodopa Amantadine |
Dopaminergic | Yes | No |
| Pimozide Thioridazine |
Antipsychotic | Yes | Yes |
| Fentanyl Tramadol |
Opioids | Yes | Yes |
| Amitriptyline Nortriptyline Imipramine Desipramine |
Tricyclic antidepressant | Yes | Yes |
| Venlafaxine Desvenlafaxine Duloxetine |
SNRIs | Yes | Yes |
| St. John’s Wort | Herbal | Yes | Yes |
| Phenytoin Fosphenytoin |
Antiepileptic | Yes | Yes |
| Lithium | Mood stabilizer | Yes | Yes |
| Ibuprofen Naproxen Aspirin |
NSAIDs | No | Yes |
| Warfarin | Anticoagulant | No | Yes |
*Consult a healthcare professional for other drug interactions
Warnings of Wellbutrin and Prozac
Both drug labels for Wellbutrin and Prozac contain black box warnings about suicidal thoughts and behaviors. There may be an increased risk of worsened depression while taking Wellbutrin or Prozac. Seek immediate medical attention if your symptoms don’t improve or you experience suicidal thoughts and behaviors.
There may be an increased risk of seizures while taking Wellbutrin, especially in higher doses. The use of Wellbutrin is also associated with an increased risk of high blood pressure, mania, psychosis, and glaucoma in certain people. Consult a healthcare provider if you have had a history of these conditions before taking Wellbutrin.
Like Wellbutrin, Prozac also carries a risk of seizures, mania, and glaucoma. In addition, the use of Prozac can also increase the risk of serotonin syndrome. Signs and symptoms of serotonin syndrome include confusion, rapid heart rate, and muscle stiffness, among others. Low sodium levels (hyponatremia), heart rhythm problems (QT prolongation), and abnormal bleeding have also been reported with Prozac in certain people.
Seek medical advice from a healthcare provider prior to starting treatment with Wellbutrin or Prozac.
Frequently asked questions about Wellbutrin vs. Prozac
What is Wellbutrin?
Wellbutrin is an aminoketone antidepressant that is FDA approved to treat major depressive disorder. It comes in an immediate-release, sustained-release, and extended-release form. In addition to treating major depressive disorder, Wellbutrin XL is also approved to prevent seasonal affective disorder. The generic name of Wellbutrin is bupropion.
What is Prozac?
Prozac is a selective serotonin reuptake inhibitor (SSRI) that is FDA approved to treat major depressive disorder. As an SSRI antidepressant, Prozac can also treat depression associated with bipolar disorder. Prozac is also approved to treat other mental health conditions, including OCD, panic disorder, bulimia, and premenstrual dysphoric disorder (as Sarafem). Prozac comes in a daily or weekly oral capsule. The generic name of Prozac is fluoxetine.
Are Wellbutrin and Prozac the same?
Both Wellbutrin and Prozac are antidepressant medications but they work in different ways. Wellbutrin is an aminoketone that works by increasing the levels of norepinephrine and dopamine in the brain. Prozac is an SSRI that works by increasing the levels of serotonin in the brain. A doctor who specializes in psychiatry may prescribe these prescription drugs to treat various mental health conditions, primarily depression.
Is Wellbutrin or Prozac better?
Wellbutrin and Prozac are similarly effective for treating depression. The best antidepressant is the one that causes the least side effects and is more cost effective, depending on the situation. Wellbutrin causes less sexual side effects and weight gain than SSRIs like Prozac. Other SSRIs include Paxil (paroxetine), Zoloft (sertraline), Lexapro (escitalopram), and Celexa (citalopram). Prozac may be more appropriate than Wellbutrin to treat depression in an individual with bipolar disorder, bulimia, or OCD. Antidepressant medications often work better in combination with psychotherapy.
Can I use Wellbutrin or Prozac while pregnant?
Wellbutrin may be prescribed to treat depression during pregnancy. However, there may be a risk of birth defects and miscarriage while using Wellbutrin during pregnancy. Prozac is not recommended during late pregnancy due to the risk of pulmonary hypertension, respiratory distress, and other problems in the infant. Wellbutrin and Prozac may pass into the breast milk. Consult a healthcare provider before taking an antidepressant while pregnant or breastfeeding.
Can I use Wellbutrin or Prozac with alcohol?
It is not generally recommended to drink alcohol while taking Wellbutrin or Prozac. Combining alcohol with antidepressants can increase the risk of side effects such as drowsiness and dizziness. Therefore, alcohol consumption should be monitored or minimized while taking Wellbutrin or Prozac.