Tizanidine alternatives: What can I take instead of tizanidine?

In this article:

• What can I take in place of tizanidine?
• Compare tizanidine to alternatives
• Top 5 tizanidine alternatives
• Natural alternatives to tizanidine
• How to switch to a tizanidine alternative

In this article

• What can I take in place of tizanidine?
• Compare tizanidine to alternatives
• Top 5 tizanidine alternatives
• Natural alternatives to tizanidine
• How to switch to a tizanidine alternative

Tizanidine is a generic prescription muscle relaxant available as brand-name Zanaflex, which is approved by the Food and Drug Administration (FDA) for treating spasticity, a condition in which muscles stiffen or tighten, preventing normal fluid movement. Tizanidine is also used off-label (for a non-FDA-approved use) for musculoskeletal pain. In addition, its sedative effects may offer relief to patients with insomnia caused by severe muscle spasms (but this benefit is also not FDA approved).

Although tizanidine is effective for treating spasticity, it isn’t for everyone. Its effects don’t last long, and it should be used during times when relief from muscle spasms is most needed for daily activities. It’s also not ideal for people with kidney or liver problems. 

Taking tizanidine with alcohol or the following medications could increase the risk of side effects like drowsiness, dizziness, and impaired coordination:

• Oral contraceptives (birth control pills)
• Central nervous system (CNS) depressants (medicines that slow down the brain, like sedatives or sleeping pills)

Always consult your healthcare provider before taking tizanidine with any other medications or substances.

RELATED: Tizanidine interactions to avoid

Tizanidine is generally well-tolerated, but side effects can occur. Drowsiness, dry mouth, and muscle weakness are the most frequently reported side effects of tizanidine. 

What can I take in place of tizanidine?

If you’re looking for an alternative to tizanidine due to side effects, there are other options you can discuss with your healthcare provider for treating muscle spasms, pain, and spasticity. Tizanidine alternatives include other muscle relaxants, medications with similar effects, and non-prescription options that may be more suitable depending on your needs. 

Top 5 tizanidine alternatives

The following are some of the most commonly recommended alternatives to tizanidine:

1. Baclofen 

Baclofen is another muscle relaxant often prescribed to people with muscle spasticity due to multiple sclerosis or spinal cord injuries. It works by acting on the CNS to reduce muscle stiffness and improve mobility. Baclofen is typically well-tolerated but may cause drowsiness, dizziness, and weakness. It’s available in tablet form and is often taken three to four times daily.

2. Cyclobenzaprine 

Cyclobenzaprine is a well-studied muscle relaxant to treat and provide short-term relief from muscle spasms and pain. It has demonstrated effectiveness in managing various conditions, including low back pain, and is sometimes prescribed off-label for fibromyalgia. Its sedative properties may also benefit individuals experiencing insomnia related to severe muscle spasms. Cyclobenzaprine is available in both immediate-release tablets and extended-release (ER) capsules, with the latter offering the convenience of once-daily dosing. Unlike tizanidine, which is more suited for treating spasticity, cyclobenzaprine is ideal for acute muscle spasms. However, it can cause side effects such as drowsiness, dry mouth, and dizziness. Individuals with hyperthyroidism, heart conditions, or liver disease should avoid it.

3. Methocarbamol 

Methocarbamol is a muscle relaxant that works by slowing down the nervous system to reduce muscle spasms and allow the body to relax. It’s a good alternative to tizanidine for those who need a less sedative option. However, it can still cause drowsiness in some users. Methocarbamol is often prescribed for acute muscle pain due to strains or sprains and is available in tablet and injectable forms.

4. Valium 

Valium (diazepam) is a benzodiazepine used to treat muscle spasms, alcohol withdrawal symptoms, anxiety disorders, and seizures. It works by calming the brain and nerves and relieving muscle stiffness. Valium can cause drowsiness, fatigue, and weakness, similar to tizanidine. Due to its sedative effects and potential for dependency, it’s typically prescribed for short-term use. Valium is classified as a Schedule IV controlled substance due to its potential for abuse and dependence.

5. Metaxalone 

Metaxalone is a muscle relaxant similar to tizanidine, primarily used to treat muscle spasms and pain. Although clinical trial data for metaxalone is limited, it may be a viable option for a muscle relaxer with fewer sedative effects. While muscle relaxants typically cause sedation, metaxalone is associated with less dizziness and drowsiness than other skeletal muscle relaxants. However, it should be avoided by those with a history of anemia, kidney issues, or liver disease.

Over-the-counter pain relievers

If muscle relaxants make you tired or dizzy, over-the-counter (OTC) pain relievers may be an option. OTC pain relievers like nonsteroidal anti-inflammatory drugs (NSAIDs) or Tylenol (acetaminophen) can be effective in managing muscle pain. Some popular NSAIDs include Advil or Motrin (ibuprofen), Aleve (naproxen), and aspirin. You can ask your healthcare provider for medical advice on which OTC pain reliever would be best for you. Your provider may recommend trying one of these medicines alone or in combination with a muscle relaxant.

Natural alternatives to tizanidine

When it comes to easing muscle tension and pain, many people are turning to natural and nonprescription alternatives that offer a gentler approach to relief. Remember, before trying any new treatment, it’s always a good idea to consult your healthcare provider. They can help you determine the best approach for your needs and ensure you make safe and informed choices.

Here are some alternatives:

• Physical therapy can help reduce pain and muscle strains. It involves strengthening muscles, improving flexibility, and teaching the body to move more efficiently.
• Acupuncture is a traditional Chinese practice that involves inserting needles into specific points on your body. The American College of Physicians recommends it as a first-line chronic low back pain treatment.
• Magnesium is important for muscle function and may help reduce muscle cramps and spasms. Some studies have shown that magnesium supplements can be effective for certain types of muscle pain, especially in people who are magnesium-deficient.
• Cannabidiol (CBD) oil has gained attention for its potential to help with pain relief and muscle relaxation. While more research is needed, some people find that CBD oil can be a helpful supplement.

How to switch to a tizanidine alternative

Discuss all your health conditions and symptoms and explain why you’re considering a switch. They can help you choose the best alternative based on your health condition and the medications you are already taking.

Suddenly stopping tizanidine without talking with your healthcare provider can lead to serious withdrawal symptoms such as increased heart rate, tremors, and anxiety. To avoid this, your healthcare provider may recommend gradually reducing your dose of tizanidine while introducing the new medication. Report any side effects or concerns you may have to your healthcare provider.