Meloxicam and naproxen: Uses, differences, and side effects

In this article:

• Main differences between meloxicam and naproxen
• Conditions treated
• Efficacy
• Coverage and cost comparison
• Side effects
• Interactions
• Warnings
• FAQs

In this article

• Main differences between meloxicam and naproxen
• Conditions treated
• Efficacy
• Coverage and cost comparison
• Side effects
• Interactions
• Warnings
• FAQs

Meloxicam and naproxen are two common analgesics that treat inflammatory conditions like osteoarthritis and rheumatoid arthritis. They belong to the nonsteroidal anti-inflammatory drugs (NSAIDs) family. These medications block cyclooxygenase (COX) enzymes, which produce prostaglandins involved in pain and inflammation. 

Both drugs are widely available and often covered by insurance and Medicare, making them accessible to many patients. However, they may differ in their effectiveness, side effects, and dosages. Ultimately, deciding between meloxicam and naproxen depends on individual medical conditions and the recommendations of a healthcare provider.

What are the main differences between meloxicam and naproxen?

Meloxicam is a selective COX-2 inhibitor that mainly blocks the COX-2 enzyme. As a result, it may have a lower risk of gastrointestinal side effects than non-selective NSAIDs like naproxen, which block both COX-1 and COX-2 enzymes.

Meloxicam may be considered more potent and longer-lasting than naproxen, making it ideal for conditions needing steady pain management. It is usually prescribed at 7.5 or 15 mg once daily and can be used in adults and children over two years old who weigh more than 60 kg (132 lbs).

Naproxen, commonly known by the brand name Aleve and Naprosyn, is available in over-the-counter (OTC) and prescription forms. It comes in various dosages, including 250 mg, 375 mg, and 500 mg. Unlike meloxicam, naproxen usually requires dosing two to three times daily for effective pain relief.

Conditions treated by meloxicam and naproxen

Meloxicam and naproxen are NSAIDs approved by the U.S. Food and Drug Administration (FDA) to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. While naproxen is also approved to treat an inflammatory spinal condition called ankylosing spondylitis, meloxicam may be used off-label for this purpose. 

Naproxen is also approved to treat pain from menstrual cramps, tendonitis, bursitis, and gout. Meloxicam may sometimes be prescribed off-label for these conditions. In addition, meloxicam and naproxen may be recommended for acute pain from dental procedures, injuries, and migraines. 

Off-label medications are prescribed for conditions that they are not officially approved for, based on a doctor’s judgment and evidence that they might help with those conditions.

Is meloxicam or naproxen more effective?

Clinical trials show that meloxicam and naproxen are effective medications for pain relief compared to placebo. The preferred medication will depend on the overall condition of the person being treated.

There are limited head-to-head trials directly comparing meloxicam and naproxen. One double-blind clinical trial compared the effectiveness of meloxicam and naproxen over six months. Both medications were similarly effective; however, meloxicam led to fewer stomach issues. Only 30.3% of those taking meloxicam had gastrointestinal problems, while 44.7% of naproxen users experienced such issues. In addition, no ulcers were seen in the meloxicam group, while two patients on naproxen developed ulcers. Always consult a healthcare provider for the most appropriate treatment option. A healthcare provider will consider your overall medical condition and other medications you take before recommending one over the other. 

Coverage and cost comparison of meloxicam vs. naproxen

Meloxicam and naproxen are widely available in generic and brand-name versions at most pharmacies. Health insurance plans typically cover both drugs, and Many Medicare Part D plans also include them.

Without insurance, the costs of these medications can vary depending on the pharmacy and location. Naproxen may be a cheaper drug. In addition, the OTC form of naproxen may be easier to obtain than meloxicam, which requires a prescription. A SingleCare prescription discount card may help save on the retail costs of meloxicam and naproxen. 

Common side effects of meloxicam vs. naproxen

As NSAIDs, meloxicam and naproxen have similar side effects. The most common side effects of both drugs include stomach pain, diarrhea, gas, and indigestion, among other digestive side effects. 

Serious side effects of NSAIDs may include serious gastrointestinal side effects, such as peptic ulcers, and cardiovascular problems, such as heart attacks and strokes. However, meloxicam may have a higher risk of cardiovascular events, while naproxen may have a higher risk of gastrointestinal bleeding.

Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.

Source: DailyMed (Meloxicam), DailyMed (Naproxen)

Drug interactions of meloxicam vs. naproxen

Meloxicam and naproxen share similar drug interactions. When taken with blood thinners like warfarin or aspirin or certain antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), there is an increased risk of bleeding.

These NSAIDs can also reduce the effectiveness of blood pressure medications such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and beta blockers. People taking these combinations should have their blood pressure monitored regularly. In addition, meloxicam and naproxen can decrease the effect of diuretics like furosemide and thiazides. 

For people using digoxin, taking meloxicam or naproxen may increase digoxin levels in the blood, requiring close monitoring of digoxin levels.

Consult a healthcare professional for other possible drug interactions

Warnings of meloxicam and naproxen

Meloxicam and naproxen come with several warnings you should be aware of before starting treatment. Here are some important points to consider:

• Liver and kidney problems: Both meloxicam and naproxen can harm your liver. If you notice symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, stop taking the medication and contact your doctor immediately. Meloxicam and naproxen can also affect your kidneys. If you have kidney disease or other conditions like heart failure or dehydration, you should have your kidney function checked regularly.
• High blood pressure: NSAIDs can make it harder for some blood pressure medicines to work. If you take meloxicam or naproxen, it’s important to monitor your blood pressure regularly.
• Heart issues: If you have severe heart problems, using these medications can make them worse. Only use them if your doctor thinks the benefits are worth the risks.
• Allergic reactions: These drugs can cause severe allergic reactions, including difficulty breathing, swelling, and rash. Seek emergency help if you experience any of these symptoms.
• Asthma: If you have asthma that’s triggered by aspirin, you should not take meloxicam or naproxen. Even if your asthma is not aspirin-sensitive, monitor your symptoms carefully.
• Pregnancy risks: If you’re pregnant, especially between 20 and 30 weeks, talk to your doctor before using these medications. They can cause problems for the baby, including kidney issues and complications with the baby’s heart.

Speak with a healthcare provider about other potential warnings and precautions before starting an NSAID. 

Frequently asked questions about meloxicam vs. naproxen

What is meloxicam?

Meloxicam is a COX-2 selective NSAID used to relieve pain and inflammation. It is commonly prescribed for conditions like osteoarthritis and rheumatoid arthritis. It is available with a prescription and is typically taken once daily. 

What is naproxen?

Naproxen is a non-selective NSAID used for pain and inflammation. It is approved for various inflammatory conditions, including arthritis, tendonitis, bursitis, and gout. Naproxen is available over the counter or with a prescription. It is typically taken two to three times daily. 

Are meloxicam and naproxen the same?

Meloxicam and naproxen are both NSAIDs, but they are not the same. Meloxicam is considered more potent and has a longer duration of action, requiring lower dosages and less frequent administration. On the other hand, naproxen may be taken multiple times per day and generally has a shorter duration of action. Meloxicam’s selective inhibition of COX-2 enzymes results in fewer gastrointestinal side effects than naproxen, which inhibits both COX-1 and COX-2 enzymes. 

Is meloxicam or naproxen better?

The effectiveness of meloxicam versus naproxen depends on the individual’s condition and how their body reacts to the medication. Meloxicam may be more effective for the long-term management of conditions like arthritis because of its once-daily dosing and fewer gastrointestinal side effects. However, naproxen may be more effective for acute pain relief in situations like muscle pain or menstrual cramps.

Can I use meloxicam or naproxen while pregnant?

Both meloxicam and naproxen are generally not recommended during pregnancy, especially in the third trimester. They can potentially cause complications such as premature closure of the ductus arteriosus in the fetus, leading to serious issues. Always consult your healthcare provider if you are pregnant or planning to become pregnant while using these medications.

Can I use meloxicam or naproxen with alcohol?

Using meloxicam or naproxen with alcohol is not recommended. Alcohol can increase the risk of gastrointestinal issues such as stomach ulcers and bleeding, which are also potential side effects of these NSAIDs.

Is meloxicam stronger than naproxen?

Meloxicam is generally considered to be more potent than naproxen. It requires a lower dosage and can provide longer-lasting relief due to its longer half-life. This makes it particularly useful for chronic conditions that require ongoing management.

Can you take meloxicam and naproxen together?

Taking meloxicam and naproxen together is generally not recommended. Both medications are NSAIDs, and combining them can increase the risk of side effects such as gastrointestinal bleeding, kidney problems, and cardiovascular issues.