Delsym vs. Robitussin Long-Acting CoughGels: Differences, Similarities, and Which One is Better For You

In this article:

• Main differences
• Conditions treated
• Cost comparison
• Side effects
• Interactions
• Warnings
• FAQs

In this article

• Main differences
• Conditions treated
• Cost comparison
• Side effects
• Interactions
• Warnings
• FAQs

Delsym and Robitussin Long-Acting CoughGels are over-the-counter cough medicines that temporarily relieve coughing. Both contain the active ingredient dextromethorphan, which helps suppress the cough reflex and provides temporary relief from a persistent cough. While they contain the same active ingredient, there are differences in dosage forms, pricing, and other factors. Continue reading to learn more about Delsym and Robitussin Long-Acting CoughGels. 

What are the main differences between Delsym and Robitussin Long-Acting CoughGels?

Delsym and Robitussin Long-Acting CoughGels are two popular over-the-counter medications used to relieve cough symptoms. Both medications are approved by the U.S. Food and Drug Administration (FDA). They both contain the active ingredient dextromethorphan, a cough suppressant that helps temporarily relieve a dry, hacking cough. Both Delsym and Robitussin Long-Acting CoughGels use an extended-release formula of dextromethorphan to provide extended relief. Delsym is available as a cough syrup and an oral caplet, while Robitussin Long-Acting CoughGels are available in oral capsule form. 

It’s important to note that neither of these products includes guaifenesin, an expectorant commonly found in many cough medications. Guaifenesin helps break up and thin mucus, making it easier to clear from the airways, which is beneficial for chest congestion and wet, mucusy coughs.

There are also many multi-symptom cough, flu, and cold medicines available that contain various ingredients, including guaifenesin, dextromethorphan, decongestants like pseudoephedrine, antihistamines like diphenhydramine, and acetaminophen. These additional ingredients address symptoms such as mild pain, fever, stuffy or runny nose, and sore throat. This article will specifically compare Delsym and Robitussin Long-Acting CoughGels.

Main differences between Delsym and Robitussin Long-Acting CoughGels
	Delsym	Robitussin Long-Acting CoughGels
Drug class	Cough suppressant; antitussive	Cough suppressant; antitussive
Brand/generic status	Brand and generic	Brand and generic
What is the generic name?	Dextromethorphan (dextromethorphan polistirex)	Dextromethorphan
What form(s) does the drug come in?	Oral liquid Oral caplets	Oral capsules
What is the standard dosage?	Varies by age; follow dosing directions on the package.  Delsym liquid is dosed every 12 hours as needed, as the long-acting formulation provides up to 12 hours of cough relief. Delsym caplets are dosed every 6 to 8 hours as needed.	Ages 12 years and older: Take 2 capsules by mouth every 6 to 8 hours as needed.
How long is the typical treatment?	Short-term; taken as needed	Short-term; taken as needed
Who typically uses the medication?	Liquid: adults and pediatric patients 4 years and older Caplet: adults and adolescents 12 years and older	Adults and children 12 years and older

Conditions treated by Delsym and Robitussin Long-Acting CoughGels

Delsym and Robitussin Long-Acting CoughGels can be used to relieve cough temporarily. They are especially useful in non-productive coughs such as the common cold and bronchitis. These medications help control the impulse to cough, which can be helpful for getting a good night’s sleep. However, the medications do not have a direct sedative effect to make you fall asleep.

It’s important to note that while Delsym and Robitussin Long-Acting CoughGels can help relieve symptoms, they do not treat the underlying cause of an infection. If you have a bacterial infection, antibiotics may be required. These over-the-counter medications are meant to provide symptom relief. Always consult a healthcare provider for medical guidance. 

Condition	Delsym	Robitussin
Cough	Yes	Yes

Cost comparison of Delsym vs. Robitussin Long-Acting CoughGels

Both Delsym and Robitussin Long-Acting CoughGels are available over the counter in both brand-name and generic options. Prices can vary depending on the product you choose. To find the most cost-effective option, consult with your pharmacist. Typically, insurance plans and Medicare do not cover these medications, though there may be exceptions.

Common side effects of Delsym and Robitussin Long-Acting CoughGels

Both Delsym and Robitussin Long-Acting CoughGels contain dextromethorphan, which can lead to similar common side effects, including:

• Nausea and vomiting
• Dizziness
• Drowsiness
• Restlessness
• Irritability

In rare cases, an allergic reaction may occur. Seek emergency medical help if you experience any of the following symptoms after using Delsym or Robitussin Long-Acting CoughGels:

• Rash, hives, or itching
• Difficulty breathing or swallowing
• Swelling of the face, lips, tongue, or throat

Another potentially serious side effect is serotonin syndrome, which will be discussed in the Drug Interactions section.

This list does not include all possible side effects. For more information about the potential side effects of Delsym and Robitussin Long-Acting CoughGels, consult your healthcare provider or pharmacist.

Drug interactions of Delsym vs. Robitussin Long-Acting CoughGels

Before using Delsym or Robitussin Long-Acting CoughGels, tell your healthcare provider or pharmacist about all your medications, including prescription and over-the-counter (OTC) drugs, vitamins, and supplements.

Be aware that combining these medications with others that affect serotonin levels can lead to a potentially life-threatening condition known as serotonin syndrome. This condition results from a buildup of excess serotonin in the body and can cause symptoms ranging from mild agitation and anxiety to severe effects like high fever, seizures, irregular heartbeat, and loss of consciousness. Seek emergency medical attention if you experience symptoms of serotonin syndrome.

Delsym and Robitussin Long-Acting CoughGels contain dextromethorphan, which is associated with this interaction. Although the table below lists examples of interacting medications, it does not list every possible interaction. Many drugs are associated with serotonin syndrome, so always consult with a healthcare provider or pharmacist before starting either Delsym or Robitussin Long-Acting CoughGels.

Drug	Drug Class	Interacts with Delsym?	Interacts with Robitussin Long-Acting CoughGels?
Escitalopram  Fluoxetine Paroxetine Sertraline	SSRI antidepressants	Yes	Yes
Amitriptyline  Nortriptyline	Tricyclic antidepressants	Yes	Yes
Desvenlafaxine Duloxetine Venlafaxine	SNRI antidepressants	Yes	Yes
Bupropion  Mirtazapine	Other antidepressants	Yes	Yes
Linezolid  Phenelzine  Rasagiline Selegiline  Tranylcypromine	MAO inhibitors	Yes (must separate use by at least 14 days)	Yes (must separate use by at least 14 days)
Almotriptan  Eletriptan  Rizatriptan Sumatriptan Zolmitriptan	Triptans for migraine treatment	Yes	Yes
Fentanyl  Hydrocodone  Oxycodone  Tramadol	Opioid pain medications	Yes	Yes
Amphetamine/dextroamphetamine Methylphenidate	Central nervous system (CNS) stimulants	Yes	Yes
Ondansetron	5-HT3 receptor antagonist	Yes	Yes
Lithium	Antimanic agent	Yes	Yes
St. John’s wort Tryptophan	Dietary supplements	Yes	Yes

Warnings of Delsym and Robitussin Long-Acting CoughGels

Before using Delsym or Robitussin Long-Acting CoughGels, tell your healthcare provider or pharmacist about your medical conditions, including whether you are pregnant or breastfeeding. Follow the dosing instructions on the package carefully, and always use the provided dosing cup or a medicinal measuring device for the liquid formulation, as household spoons are not accurate for measuring medicine.

Here are some important warnings for both medications:

• Do not use Delsym or Robitussin Long-Acting CoughGels if you are currently taking a monoamine oxidase inhibitor (MAOI)—a medication often prescribed for certain mental health conditions or Parkinson’s disease—or if you have taken an MAOI within the last two weeks. If you are not sure whether your medication contains an MAOI, consult your healthcare provider or pharmacist.
• Consult your healthcare provider before using Delsym or Robitussin Long-Acting CoughGels if you have a chronic cough due to smoking, asthma, or chronic obstructive pulmonary disease (COPD).
• Discontinue use and contact your healthcare provider if your cough persists for more than seven days, returns after going away, or is accompanied by other symptoms like fever, rash, or headache.
• Seek immediate medical attention if you suspect an overdose or contact Poison Control at 800-222-1222.

Frequently asked questions about Delsym vs. Robitussin Long-Acting CoughGels

Are Delsym and Robitussin Long-Acting CoughGels the same?

Delsym and Robitussin Long-Acting CoughGels both contain the active ingredient dextromethorphan and can temporarily relieve dry cough symptoms. However, as outlined above, they differ in available forms and dosages. 

Can I use Delsym or Robitussin Long-Acting CoughGels while pregnant?

Consult your healthcare provider if you are pregnant before using Delsym or Robitussin Long-Acting CoughGels.

Can I use Delsym or Robitussin Long-Acting CoughGels with alcohol?

Combining Delsym or Robitussin Long-Acting CoughGels with alcohol is not recommended. Both medications can cause drowsiness, and alcohol may intensify this effect, potentially worsening side effects and impairing judgment. Additionally, alcohol can weaken the immune system, making it more difficult to recover from your illness.

Which Robitussin is best for coughing?

It depends on the type of cough you have. Robitussin Long-Acting CoughGels are better for a dry, non-productive cough. However, you may need an expectorant if you have a wet, productive cough. In that case, Robitussin DM could be the better option. Robitussin DM combines dextromethorphan with guaifenesin, an expectorant that helps break up mucus (phlegm), making it easier to clear from your airways.